Figure 8From: Intra-arterial administration of recombinant tissue-type plasminogen activator (rt-PA) causes more intracranial bleeding than does intravenous rt-PA in a transient rat middle cerebral artery occlusion model IA rt-PA 30 mg/kg animals. Rats were subjected to 6 hours MCAo with reflow. Treatment with IA rt-PA 30 mg/kg commenced 1 minute before reflow. Photographs of the gross brain and a TTC stained coronal section from each animal in the group are displayed. Thin arrows indicate hemorrhage. Thick arrows indicate damage to the hypothalamus.Back to article page