Pre Ischemia | Saline IA (n = 5) | rt-PA: 1 mg/kg IA (n = 5) | rt-PA: 5 mg/kg IA (n = 7) | rt-PA: 10 mg/kg IA (n = 5) | rt-PA: 30 mg/kg IA (n = 5) | rt-PA: 10 mg/kg IV (n = 5) | rt-PA: 30 mg/kg IV (n = 5) |
---|---|---|---|---|---|---|---|
pH | 7.43 ± 0.03 | 7.48 ± 0.01 | 7.49 ± 0.01 | 7.47 ± 0.02 | 7.46 ± 0.03 | 7.51 ± 0.02 | 7.44 ± 0.01 |
PaCO2 (mmHg) | 39.1 ± 4.5 | 36.2 ± 1.0 | 36.2 ± 1.2 | 38.7 ± 1.2 | 38.3 ± 2.5 | 35.2 ± 2.1 | 41.3 ± 1.6 |
PaO2 (mmHg) | 99.2 ± 6.5 | 118.0 ± 6.0 | 111.9 ± 4.0 | 164.6 ± 7.5 | 109.0 ± 8.7 | 110.0 ± 11.9 | 106.4 ± 4.5 |
Glu (mg/dL) | 138 ± 9 | 137 ± 4 | 131 ± 8 | 152 ± 10 | 136 ± 13 | 139 ± 6 | 136 ± 13 |
MABP (mmHg) | 116 ± 17 | 105 ± 7 | 145 ± 12 | 119 ± 13 | 148 ± 15 | 132 ± 10 | 141 ± 15 |
HR (beats/min) | 362 ± 10 | 353 ± 6 | 332 ± 6 | 351 ± 12 | 358 ± 11 | 347 ± 16 | 334 ± 40 |
Hct (%PCV) | 43.8 ± 1.9 | 45.6 ± 0.7 | 44.6 ± 0.6 | 45.6 ± 0.5 | 44.6 ± 0.7 | 45.2 ± 0.5 | 45.2 ± 0.5 |
Body Temp (°C) | 37.1 ± 0.1 | 37.0 ± 0.0 | 37.1 ± 0.1 | 37.0 ± 0.0 | 37.1 ± 0.1 | 37.0 ± 0.0 | 37.1 ± 0.0 |
Body Wt (g) | 329.0 ± 7.0 | 328.4 ± 6.5 | 345.4 ± 3.2 | 339.6 ± 12.7 | 318.2 ± 7.8 | 328.6 ± 14.3 | 330.8 ± 2.0 |
Pre Reflow | |||||||
pH | 7.47 ± 0.03 | 7.42 ± 0.02 | 7.48 ± 0.02 | 7.44 ± 0.01 | 7.45 ± 0.02 | 7.42 ± 0.04 | 7.45 ± 0.02 |
PaCO2 (mmHg) | 34.6 ± 2.7 | 38.7 ± 2.0 | 36.6 ± 1.2 | 38.1 ± 1.2 | 37.1 ± 1.0 | 38.6 ± 2.6 | 38.9 ± 1.6 |
PaO2 (mmHg) | 157.4 ± 2.7 | 167.4 ± 17.6 | 167.1 ± 10.2 | 164.6 ± 7.5 | 149.4 ± 12.3 | 145.8 ± 13.4 | 136.0 ± 6.6 |
Glu (mg/dL) | 195 ± 38 | 348 ± 63 | 299 ± 49 | 379 ± 81 | 196 ± 13 | 243 ± 44 | 204 ± 11 |
MABP (mmHg) | 145 ± 18 | 138 ± 16 | 117 ± 14 | 145 ± 12 | 137 ± 14 | 138 ± 19 | 164 ± 16 |
HR (beats/min) | 377 ± 7 | 370 ± 9 | 347 ± 9 | 367 ± 7 | 368 ± 9 | 364 ± 16 | 340 ± 34 |
Hct (%PCV) | 43.4 ± 2.6 | 46.0 ± 1.0 | 45.3 ± 0.7 | 46.4 ± 1.1 | 42.6 ± 1.0 | 45.6 ± 0.8 | 45.6 ± 1.0 |
Body Temp (°C) | 37.1 ± 0.1 | 37.1 ± 0.0 | 37.0 ± 0.1 | 37.1 ± 0.0 | 37.0 ± 0.1 | 37.6 ± 0.4 | 37.0 ± 0.1 |