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Figure 1 | Experimental & Translational Stroke Medicine

Figure 1

From: Granulocyte-colony stimulating factor for stroke treatment: mechanisms of action and efficacy in preclinical studies

Figure 1

G-CSF reduces infarct sizes and enhances functional recovery in stroke models by several mechanisms of action, such as the induction of anti-apoptotic pathways, neurogenesis and angiogenesis. Thereby G-CSF acts as a direct protectant for neurons expressing its receptor. G-CSF's influences on immunocompetence and inflammation parameters are potential additional effects.

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