The T H 1 response to MBP in brain is not predictive of rotarod performance ( a ), but animals with a T H 1 response to MBP in spleen have a shorter latency to fall from the rotarod ( ie . worse performance) 3 months after MCAO than animals without a T H 1 response to MBP in spleen ( b ). Point estimates represent the mean and the bars represent the standard error of the mean (*P < 0.05 using the t-test). There is a correlation between the humoral response to MBP (antibody titer) and the concentration of circulating fractalkine (c) and the concentration of circulating fractalkine is correlated with the degree of brain atrophy (d) (ie. higher concentrations of fractalkine are associated with more brain atrophy).