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Table 1 Immune status at 1 and 3 months following middle cerebral artery occlusion.

From: Long term immunologic consequences of experimental stroke and mucosal tolerance

time to sacrifice 1 month 3 months 1 vs. 3 months
brain OVA
N = 17
MBP
N = 16
P OVA
N = 8
MBP
N = 17
P OVA MBP
T H 1 6 (35) 1 (6) 0.033 4 (50) 6 (35) NS NS 0.041
T REG 5 (29) 5 (31) NS 0 3 (18) NS 0.086 NS
spleen OVA
N = 21
MBP
N = 21
P OVA
N = 13
MBP
N = 22
P OVA MBP
T H 1 8 (38) 1 (6) 0.001 6 (46) 5 (23) NS NS 0.089
T REG 0 7 (33) 0.001 1 (8) 6 (27) NS NS NS
  1. Animals are considered to have a TH 1(+) response to MBP if the ratio of the relative increase in the number of MBP-specific IFN secreting cells to the relative increase in the number of MBP-specific TGF secreting cells is at least 1.48. Conversely, they are considered to have a TREG response to MBP if the ratio of the relative increase in the number of MBP-specific IFN secreting cells to the relative increase in the number of MBP-specific TGF secreting cells is ≤ 1 ÷ 1.48 (0.68).