Table 1 Overview of experimental stroke models
From: Rodent models of focal cerebral ischemia: procedural pitfalls and translational problems
Cerebral Ischemia | Etiology | Reperfusion (transient ischemia) or permanent ischemia | Examples |
|---|---|---|---|
Global (complete or incomplete) = model of circulatory arrest or severe hypotension | Intravascular | Transient or permanent | Cardiac arrest with or without cardiopulmonary resuscitation |
| Â | Extravascular | Transient or permanent | Cervical compression by neck cuff; ligation of several brain-supplying arteries |
Focal | Intravascular | Transient or permanent | Intraluminal thread middle cerebral artery occlusion model |
| Â | Extravascular | Transient or permanent | Surgical middle cerebral artery occlusion models using ligation, clipping, electrocauterization etc.; endothelin-1-induced middle cerebral artery occlusion |
Multifocal | Intravascular | Transient (spontaneous lysis or thrombolytic therapy possible in blood clots) or permanent | Embolization models using blood clots, microspheres or other embolus material |