Figure 2

Infarct volumes and functional outcome. Infarct volumes (A) and functional outcome scores (B: modified Bederson test score; C: foot fault test; D: grip test score) of interleukin-18 wild-type and knock-out mice. The results are diagrammed as whisker boxes with medians. Boxes represent interquartile ranges and whiskers indicate extreme values. The p values resulting from Mann-Whitney U tests are given; all p values were greater than 0.05 and were thus considered insignificant. Abbreviations: wt, wild-type animals; ko, interleukin-18 knock-out animals; n, number of animals; 0 h, 0 hours (postoperatively after recovery from anesthesia); 24 h and 48 h, 24 hours and 48 hours after 1-hour middle cerebral artery occlusion.