Figure 1

Physiological parameters, and cellular ischemia and injury markers. Effects of heat exposure (ambient temperature; Ta = 42°C for 80 min) on colonic temperature (Tco), mean arterial pressure (MAP), heart rate (HR), cerebral blood flow (CBF) and the extracellular concentrations of glutamate, glycerol, and lactate/pyruvate ratio of the corpus striatum in normothermic control rats (open circles), 0.9% NaCl solution (11 ml/kg)-treated (filled circles), DXM (4 mg/kg)-treated (open squares), HES (10%, 11 ml/kg)-treated (filled squares), or the combined agent (DXM+HES)-treated rats (open triangles). The dotted line indicates time of heat stroke onset and drug injection. *P < 0.05, compared with normothermic control rats. ^† P < 0.05, compared with saline-treated rats (Ta = 42°C for 80 min).^# P < 0.05, compared with HES-treated rats (Ta = 42°C for 80 min) (ANOVA followed by Duncan's test).