Table 1 Effects of heat exposure (HE; Ta = 42°C) on both latency for the onset of heat stroke and survival time in rats treated with normal saline (NS), in rats treated with hydroxyethyl starch (HES), in rats treated with dexamethasone (DXM), and in rats treated with HES +DXM.
Treatment | Latency (mins) | Survival time (mins) |
|---|---|---|
1. Rats treated with NS and kept at 24°C | > 480†, ‡ | > 480†, ‡, # |
2. Rats treated with NS (1 ml/kg, i.v.) and kept at 42°C | 82 ± 3* | 23 ± 2*,†, ‡ |
3. Rats treated with NS (11 ml/kg, i.v.) and kept at 42°C | 79 ± 4* | 34 ± 6*, ‡ |
4. Rats treated with HES (10%, 11 ml/kg, i.v.) and kept at 42°C | 81 ± 3* | 177 ± 15*,†, # |
5. Rats treated with DXM (4 mg/kg, i.v.) and kept at 42°C | 80 ± 3* | 28 ± 7*, ‡ |
6. Rats treated with DXM (4 mg/kg, i.v.)+HES (10%, 11 ml/kg, i.v.) and kept at 42°C | 79 ± 4* | 262 ± 17*, †, ‡, # |