Skip to main content

Table 1 Effects of heat exposure (HE; Ta = 42°C) on both latency for the onset of heat stroke and survival time in rats treated with normal saline (NS), in rats treated with hydroxyethyl starch (HES), in rats treated with dexamethasone (DXM), and in rats treated with HES +DXM.

From: Attenuation of circulatory shock and cerebral ischemia injury in heat stroke by combination treatment with dexamethasone and hydroxyethyl starch

Treatment Latency (mins) Survival time (mins)
1. Rats treated with NS and kept at 24°C > 480†, ‡ > 480†, ‡, #
2. Rats treated with NS (1 ml/kg, i.v.) and kept at 42°C 82 ± 3* 23 ± 2*,†, ‡
3. Rats treated with NS (11 ml/kg, i.v.) and kept at 42°C 79 ± 4* 34 ± 6*, ‡
4. Rats treated with HES (10%, 11 ml/kg, i.v.) and kept at 42°C 81 ± 3* 177 ± 15*,†, #
5. Rats treated with DXM (4 mg/kg, i.v.) and kept at 42°C 80 ± 3* 28 ± 7*, ‡
6. Rats treated with DXM (4 mg/kg, i.v.)+HES (10%, 11 ml/kg, i.v.) and kept at 42°C 79 ± 4* 262 ± 17*, †, ‡, #
  1. NS or drugs were administered immediately after the onset of heat stroke.
  2. Values are the means ± SEM of 8 rats per group. Groups 2-6 exposed to 42°C had heat exposure withdrawn at the onset of heat stroke.*P < 0.05, compared with the corresponding control values (rats kept at 24°C; treatment 1). (one-way ANOVA, followed by Duncan's test). P < 0.05, compared with the corresponding control values (rats treated with NS (11 ml/kg) and kept at 42°C; treatment 3). (one-way ANOVA, followed by Duncan's test). P < 0.05, compared with the corresponding control values (rats treated with HES (11 ml/kg) and kept at 42°C; treatment 4). (one-way ANOVA, followed by Duncan's test). #P < 0.05, compared with the corresponding control values (rats treated with DXM (4 mg/kg) and kept at 42°C; treatment 5). (one-way ANOVA, followed by Duncan's test).