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Table 2 Effects of heat exposure (42°C for 80 min) plus 25 min room temperature (24°C) exposure on the neuronal damage score values of corpus striatum from normal saline-treated, dexamethasone(DXM), HES or the combined agent (DXM+HES)-treated ratsa.

From: Attenuation of circulatory shock and cerebral ischemia injury in heat stroke by combination treatment with dexamethasone and hydroxyethyl starch

Treatment

Score of neuronal damage (0-3)

 

striatum

1. Normal saline (1 ml/kg, i.v.)-treated rats at 24°C

0 (0, 0.75)

2. Normal saline (1 ml/kg, i.v.)-treated rats at 42°C

2 (2, 2.25)b

3. DXM (4 mg/kg, i.v.)-treated rats at 42°C

2 (2, 2)b

4. HES (10%, 11 ml/kg, i.v.)-treated rats at 42°C

1 (0.25, 1)c

5. DXM (4 mg/kg, i.v.)+HES (10%, 11 ml/kg, i.v.)-treated rats at 42°C

1 (0, 1)c

  1. aValues are means ± S.E. of 8 rats per group followed by median with Q1and Q3 in parenthesis. For determination of neuronal damage score animals were killed after 80 mins heat exposure plus 25 mins room temperature exposure. The data were evaluated by a Wilcoxon signed rank test followed by Mann-Whitney test.
  2. bP < 0.05, significance of difference from corresponding values (treatment 1, control rats).
  3. cP < 0.05 significance of difference from corresponding values (treatment 2).
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Experimental & Translational Stroke Medicine

ISSN: 2040-7378

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