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Table 1 Cytokine response

From: Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns

  Macrosphere model Human stroke tMCAO
Activation of microglia (maximum) day 3 (day 7) day 3 (day 7)37 6 h (day 3)17
Transformation from ramified to ameboid microglia in the infarct border from day 3 on days? 22 h17
Infiltration of macrophages/microglia in the infarct core day 7 day 6- day 814 6 h17
Spatial patterns of macrophages/microglia accumulation "wall-like" accumulation in the outer infarct, sparing the infarct core "wall-like" accumulation in the outer infarct, sparing the infarct core14 heterogeneous, extending in distinct patterns on a subcortical to cortical axis17
Accumulation of phagozytes day 7 day 5-84 day 317
  1. Time-points of various signs of inflammation after focal cerebral ischemia in macrosphere model, human stroke and tMCAO