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Table 1 Cytokine response

From: Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns

 

Macrosphere model

Human stroke

tMCAO

Activation of microglia (maximum)

day 3 (day 7)

day 3 (day 7)37

6 h (day 3)17

Transformation from ramified to ameboid microglia in the infarct border

from day 3 on

days?

22 h17

Infiltration of macrophages/microglia in the infarct core

day 7

day 6- day 814

6 h17

Spatial patterns of macrophages/microglia accumulation

"wall-like" accumulation in the outer infarct, sparing the infarct core

"wall-like" accumulation in the outer infarct, sparing the infarct core14

heterogeneous, extending in distinct patterns on a subcortical to cortical axis17

Accumulation of phagozytes

day 7

day 5-84

day 317

  1. Time-points of various signs of inflammation after focal cerebral ischemia in macrosphere model, human stroke and tMCAO