Figure 9From: Intra-arterial administration of recombinant tissue-type plasminogen activator (rt-PA) causes more intracranial bleeding than does intravenous rt-PA in a transient rat middle cerebral artery occlusion model IV rt-PA 10 mg/kg animals. Rats were subjected to 6 hours MCAo with reflow. Treatment with IV rt-PA 10 mg/kg commenced 1 minute before reflow. Photographs of the gross brain and a TTC stained coronal section from each animal in the group are displayed. Arrows indicate hemorrhage.Back to article page