Table 1 Experimental groups and dosing details
Group | n | Dose | [Test Article] | Injection Volume | Infusion Duration |
|---|---|---|---|---|---|
Saline | 5 | Dose Vol | --- | 1 μL/g BW | 10 min |
Vehicle | 5 | Dose Vol | --- | 1 μL/g BW | 10 min |
rt-PA, IA Infusion | 5 | 1 mg/kg | 1 mg/mL | 1 μL/g BW | 10 min |
|  | 7 | 5 mg/kg | 5 mg/mL | 1 μL/g BW | 10 min |
|  | 5 | 10 mg/kg | 5 mg/mL | 2 μL/g BW | 20 min |
|  | 5 | 30 mg/kg | 5 mg/mL | 6 μL/g BW | 60 min |
rt-PA, IV Infusion | 5 | 10 mg/kg | 5 mg/mL | 2 μL/g BW | 20 min |
|  | 5 | 30 mg/kg | 5 mg/mL | 6 μL/g BW | 60 min |