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Table 1 Experimental groups and dosing details

From: Intra-arterial administration of recombinant tissue-type plasminogen activator (rt-PA) causes more intracranial bleeding than does intravenous rt-PA in a transient rat middle cerebral artery occlusion model

Group n Dose [Test Article] Injection Volume Infusion Duration
Saline 5 Dose Vol --- 1 μL/g BW 10 min
Vehicle 5 Dose Vol --- 1 μL/g BW 10 min
rt-PA, IA Infusion 5 1 mg/kg 1 mg/mL 1 μL/g BW 10 min
  7 5 mg/kg 5 mg/mL 1 μL/g BW 10 min
  5 10 mg/kg 5 mg/mL 2 μL/g BW 20 min
  5 30 mg/kg 5 mg/mL 6 μL/g BW 60 min
rt-PA, IV Infusion 5 10 mg/kg 5 mg/mL 2 μL/g BW 20 min
  5 30 mg/kg 5 mg/mL 6 μL/g BW 60 min
  1. The infusion rate of the test article depended on the body weight (BW) of the rat. The total volumes infused averaged 0.35 mL, 0.7 mL and 1.95 mL for infusion durations of 10, 20 and 60 minutes, respectively.