Intra-arterial administration of recombinant tissue-type plasminogen activator (rt-PA) causes more intracranial bleeding than does intravenous rt-PA in a transient rat middle cerebral artery occlusion model

Table 2 Blood flow for the indicated arteries

Artery	Blood Flow (mL/min)	% EC-ICA Blood Flow*
Common Carotid Artery	3.49 ± 0.19	----
Occipital Artery	0.43 ± 0.09	----
External Carotid Artery	1.22 ± 0.28	----
Pterygopalatine Artery	1.52 ± 0.08	63%
Intra-Cranial Internal Carotid Artery (blood flow to the brain)	0.89 ± 0.04	37%

The arteries were isolated by cutdown and a perivascular blood flow probe was placed around the common carotid artery. Arteries were then sequentially occluded and blood flow for each artery was determined by subtraction. * Percent of the extra-cranial internal carotid artery (EC-ICA) blood flow delivered to these arteries (the rat EC-ICA bifurcates just before entering the skull). The values are the mean ± SEM (n = 4).

ISSN: 2040-7378