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Table 3 Physiological variables

From: Intra-arterial administration of recombinant tissue-type plasminogen activator (rt-PA) causes more intracranial bleeding than does intravenous rt-PA in a transient rat middle cerebral artery occlusion model

Pre Ischemia

Saline IA

(n = 5)

rt-PA: 1 mg/kg

IA (n = 5)

rt-PA: 5 mg/kg

IA (n = 7)

rt-PA: 10 mg/kg

IA (n = 5)

rt-PA: 30 mg/kg

IA (n = 5)

rt-PA: 10 mg/kg

IV (n = 5)

rt-PA: 30 mg/kg

IV (n = 5)

pH

7.43 ± 0.03

7.48 ± 0.01

7.49 ± 0.01

7.47 ± 0.02

7.46 ± 0.03

7.51 ± 0.02

7.44 ± 0.01

PaCO2 (mmHg)

39.1 ± 4.5

36.2 ± 1.0

36.2 ± 1.2

38.7 ± 1.2

38.3 ± 2.5

35.2 ± 2.1

41.3 ± 1.6

PaO2 (mmHg)

99.2 ± 6.5

118.0 ± 6.0

111.9 ± 4.0

164.6 ± 7.5

109.0 ± 8.7

110.0 ± 11.9

106.4 ± 4.5

Glu (mg/dL)

138 ± 9

137 ± 4

131 ± 8

152 ± 10

136 ± 13

139 ± 6

136 ± 13

MABP (mmHg)

116 ± 17

105 ± 7

145 ± 12

119 ± 13

148 ± 15

132 ± 10

141 ± 15

HR (beats/min)

362 ± 10

353 ± 6

332 ± 6

351 ± 12

358 ± 11

347 ± 16

334 ± 40

Hct (%PCV)

43.8 ± 1.9

45.6 ± 0.7

44.6 ± 0.6

45.6 ± 0.5

44.6 ± 0.7

45.2 ± 0.5

45.2 ± 0.5

Body Temp (°C)

37.1 ± 0.1

37.0 ± 0.0

37.1 ± 0.1

37.0 ± 0.0

37.1 ± 0.1

37.0 ± 0.0

37.1 ± 0.0

Body Wt (g)

329.0 ± 7.0

328.4 ± 6.5

345.4 ± 3.2

339.6 ± 12.7

318.2 ± 7.8

328.6 ± 14.3

330.8 ± 2.0

Pre Reflow

pH

7.47 ± 0.03

7.42 ± 0.02

7.48 ± 0.02

7.44 ± 0.01

7.45 ± 0.02

7.42 ± 0.04

7.45 ± 0.02

PaCO2 (mmHg)

34.6 ± 2.7

38.7 ± 2.0

36.6 ± 1.2

38.1 ± 1.2

37.1 ± 1.0

38.6 ± 2.6

38.9 ± 1.6

PaO2 (mmHg)

157.4 ± 2.7

167.4 ± 17.6

167.1 ± 10.2

164.6 ± 7.5

149.4 ± 12.3

145.8 ± 13.4

136.0 ± 6.6

Glu (mg/dL)

195 ± 38

348 ± 63

299 ± 49

379 ± 81

196 ± 13

243 ± 44

204 ± 11

MABP (mmHg)

145 ± 18

138 ± 16

117 ± 14

145 ± 12

137 ± 14

138 ± 19

164 ± 16

HR (beats/min)

377 ± 7

370 ± 9

347 ± 9

367 ± 7

368 ± 9

364 ± 16

340 ± 34

Hct (%PCV)

43.4 ± 2.6

46.0 ± 1.0

45.3 ± 0.7

46.4 ± 1.1

42.6 ± 1.0

45.6 ± 0.8

45.6 ± 1.0

Body Temp (°C)

37.1 ± 0.1

37.1 ± 0.0

37.0 ± 0.1

37.1 ± 0.0

37.0 ± 0.1

37.6 ± 0.4

37.0 ± 0.1

  1. Rats were subjected to MCAo with reflow as described. Blood from the tail arterial line was obtained and analyzed for blood gas values within 5 minutes of MCAo and of removal of the snare ligature (pre-reflow values). The values are the mean ± SEM.