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Table 3 Physiological variables

From: Intra-arterial administration of recombinant tissue-type plasminogen activator (rt-PA) causes more intracranial bleeding than does intravenous rt-PA in a transient rat middle cerebral artery occlusion model

Pre Ischemia Saline IA
(n = 5)
rt-PA: 1 mg/kg
IA (n = 5)
rt-PA: 5 mg/kg
IA (n = 7)
rt-PA: 10 mg/kg
IA (n = 5)
rt-PA: 30 mg/kg
IA (n = 5)
rt-PA: 10 mg/kg
IV (n = 5)
rt-PA: 30 mg/kg
IV (n = 5)
pH 7.43 ± 0.03 7.48 ± 0.01 7.49 ± 0.01 7.47 ± 0.02 7.46 ± 0.03 7.51 ± 0.02 7.44 ± 0.01
PaCO2 (mmHg) 39.1 ± 4.5 36.2 ± 1.0 36.2 ± 1.2 38.7 ± 1.2 38.3 ± 2.5 35.2 ± 2.1 41.3 ± 1.6
PaO2 (mmHg) 99.2 ± 6.5 118.0 ± 6.0 111.9 ± 4.0 164.6 ± 7.5 109.0 ± 8.7 110.0 ± 11.9 106.4 ± 4.5
Glu (mg/dL) 138 ± 9 137 ± 4 131 ± 8 152 ± 10 136 ± 13 139 ± 6 136 ± 13
MABP (mmHg) 116 ± 17 105 ± 7 145 ± 12 119 ± 13 148 ± 15 132 ± 10 141 ± 15
HR (beats/min) 362 ± 10 353 ± 6 332 ± 6 351 ± 12 358 ± 11 347 ± 16 334 ± 40
Hct (%PCV) 43.8 ± 1.9 45.6 ± 0.7 44.6 ± 0.6 45.6 ± 0.5 44.6 ± 0.7 45.2 ± 0.5 45.2 ± 0.5
Body Temp (°C) 37.1 ± 0.1 37.0 ± 0.0 37.1 ± 0.1 37.0 ± 0.0 37.1 ± 0.1 37.0 ± 0.0 37.1 ± 0.0
Body Wt (g) 329.0 ± 7.0 328.4 ± 6.5 345.4 ± 3.2 339.6 ± 12.7 318.2 ± 7.8 328.6 ± 14.3 330.8 ± 2.0
Pre Reflow
pH 7.47 ± 0.03 7.42 ± 0.02 7.48 ± 0.02 7.44 ± 0.01 7.45 ± 0.02 7.42 ± 0.04 7.45 ± 0.02
PaCO2 (mmHg) 34.6 ± 2.7 38.7 ± 2.0 36.6 ± 1.2 38.1 ± 1.2 37.1 ± 1.0 38.6 ± 2.6 38.9 ± 1.6
PaO2 (mmHg) 157.4 ± 2.7 167.4 ± 17.6 167.1 ± 10.2 164.6 ± 7.5 149.4 ± 12.3 145.8 ± 13.4 136.0 ± 6.6
Glu (mg/dL) 195 ± 38 348 ± 63 299 ± 49 379 ± 81 196 ± 13 243 ± 44 204 ± 11
MABP (mmHg) 145 ± 18 138 ± 16 117 ± 14 145 ± 12 137 ± 14 138 ± 19 164 ± 16
HR (beats/min) 377 ± 7 370 ± 9 347 ± 9 367 ± 7 368 ± 9 364 ± 16 340 ± 34
Hct (%PCV) 43.4 ± 2.6 46.0 ± 1.0 45.3 ± 0.7 46.4 ± 1.1 42.6 ± 1.0 45.6 ± 0.8 45.6 ± 1.0
Body Temp (°C) 37.1 ± 0.1 37.1 ± 0.0 37.0 ± 0.1 37.1 ± 0.0 37.0 ± 0.1 37.6 ± 0.4 37.0 ± 0.1
  1. Rats were subjected to MCAo with reflow as described. Blood from the tail arterial line was obtained and analyzed for blood gas values within 5 minutes of MCAo and of removal of the snare ligature (pre-reflow values). The values are the mean ± SEM.