Figure 1

Chronic Ang II infusion elicits dose-dependent increases in blood pressure and the adhesion of leukocytes and platelets in cerebral venules. WT mice received a 14-day infusion of Ang II subcutaneously in pumps loaded to deliver either 0, 400, 600, 800, 1000, or 2000 ng/Kg/min. (Panel A): Mean arterial blood pressure was measured in conscious mice with an indwelling femoral arterial catheter. (Panels B & C): The adhesion of leukocytes (B) and platelets (C) in cerebral venules was monitored via a cranial window by fluorescence intravital videomicroscopy. Leukocytes were labeled in vivo with Rhodamin 6G while platelets were labeled with CFDSE ex vivo. Data are shown as mean ± SEM for 6-13 mice per Ang II dose. * denotes p < 0.05 relative to saline infusion.