Role of blood cell-associated angiotensin II type 1 receptors in the cerebral microvascular response to ischemic stroke during angiotensin-induced hypertension

Table 1 Chronic angiotensin II infusion (2000 ng/kg/min) induces hypertension via blood cell associated AT1aR.

*Experimental group*	*Mean arterial pressure* (mmHg)
Wild type mice (WT) - saline loaded (- saline) (n = 9)	110.8 ± 1.8
WT - angiotensin II loaded (- Ang II) (n = 10)	125.4 ± 4.9*
AT1aR knockout mice (AT1aR ^-/- ) - Ang II (n = 6)	103.4 ± 4.0^†
WT bone marrow chimera mice reconstructed with WT bone marrow (WT→WT) - saline (n = 7)	96.6 ± 2.0
WT→WT - Ang II (n = 8)	115.1 ± 6.1^‡
AT1aR ^-/- →WT - Ang II (n = 6)	108.9 ± 3.2^†

Data are presented as mean ± SE. * denotes P < 0.05 vs WT - saline, † denotes p < 0.05 relative to WT - Ang II, ‡ denotes P < 0.05 vs WT→WT - saline

ISSN: 2040-7378