Figure 1

A: FTY720 reduces ischemic lesion size in large territorial infarctions. MCAO was performed for 3 h. FTY720 or vehicle were administered 2 h after the induction of cerebral ischemia (n = 10 in both groups). Data are depicted as box and whiskers plots showing the 25 to 75 percentile and the extreme values. Statistical significance was assessed with students unpaired t-test. ** p < 0.01. B: The functional neurological status of the mice was tested with a 5-point neuroscore after 24 h. Medians are given and statistical significance was tested with a Mann-Whitney test. ** p < 0.01.