Figure 2

A: FTY720 reduces ischemic lesion size when administered after reperfusion. MCAO was performed for 90 min and FTY720 (n = 10) or vehicle (n = 7) were applied 2 h after vessel occlusion. Data are depicted as box and whiskers plots showing the 25 to 75 percentile and the extreme values. Statistical significance was assessed with student's unpaired, two-tailed t-test. * p < 0.05. B: The functional neurological status of the mice was tested with a 5-point neuroscore after 24 h. Medians are given and statistical significance was tested with a Mann-Whitney test. n.s. = not significant.