From: The 1027th target candidate in stroke: Will NADPH oxidase hold up?
Isoform | Regulators | Product | Tissue distribution | Cellular distribution |
---|---|---|---|---|
NOX 1 | NOX1 subunits, Rac, PDI, Hsp90, hypoxia | O2 - | Brain, vessels, colon, stomach, uterus, placenta, prostate, retina. | Neurons, astrocytes, microglia, VSMCs, epithelial cells, osteoclasts, |
NOX 2 | NOX2 subunits, Rac, Hsp90, hypoxia | O2 - | Brain, vessels, liver, muscle. | Neutrophils, monocytes, macrophages, T-cells, microglia, astrocytes, ECs, fibroblasts, cardiac myocytes, hepatocytes, hemapoietic stem cells. |
NOX 4 | p22phox, PolDip2, PDI, hypoxia | H2O2 | Ubiquitous, especially kidney, vessels, lung, bone. | Neurons, astrocytes, ECs, VSMCs, fibroblasts, mesangial cells, keratinocytes, osteoclasts, hepatocytes. |
NOX 5 | no subunits, but calcium sensitive, Hsp90 | O2 - | Testis, spleen, kidney, lymphatic tissue, uterus | ECs, VSMCs, lymphocytes, and several cancer cell lines |