A-B Determination of the infarct volume by magnetic resonance imaging (MRI). Representative illustrations of T2 weighted MR sequences on days 1, 8, 29 and 60 after stroke induction (left: transversal view; right: coronal view). On the first day after stroke, all animals exhibited a circumscribed T2 hyperintensity within the supply territory of the middle cerebral artery. The further development of the ischemic lesion was characterized by a decrease of the brain edema within the first week, and an increasing organization with scar formation over time (A). The development of lesion volume did not differ significantly between any of the experimental groups (B). Values are means ± SD for 7 samples per group.