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Table 1 Physiological variables

From: Docosahexaenoic acid complexed to human albumin in experimental stroke: neuroprotective efficacy with a wide therapeutic window

 

Dose-response study

Therapeutic window study

 

Saline

DHA 5 mg/kg

Alb 0.63 g/kg

DHA-Alb

Saline

DHA 5 mg/kg

Alb, 1.25 g/kg

DHA-Alb

Alb, 1.25g/kg

DHA-Alb

    

0.32 g/kg

0.63 g/kg

1.25 g/kg

  

3h

2h

3h

4h

5h

5h

6h

7h

 

(n=6)

(n=7)

(n=6)

(n=7)

(n=5)

(n=7)

(n=7)

(n=8)

(n=8)

(n=8)

(n=8)

(n=7)

(n=9)

(n=7)

(n=9)

(n=8)

Before MCAo (15 min)

                

Rectal temperature (oC)

36.6 ± 0.1

37.3 ± 0.1

37.1 ± 0.1

36.9 ± 0.1

37.3 ± 0.2

37.1 ± 0.1

36.8 ± 0.1

36.9 ± 0.1

37.2 ± 0.1

37.0 ± 0.1

36.9 ± 0.1

36.9 ±0.1

37.0 ± 0.1

36.8 ± 0.1

37.0 ± 0.1

36.8 ± 0.1

Cranial temperature (oC)

36.6 ± 0.1

36.8 ± 0.1

36.9 ± 0.2

36.3 ± 0.1

36.8 ± 0.2

36.6 ± 0.2

36.7 ± 0.3

36.8 ± 0.2

37.1 ± 0.1

36.9 ± 0.1

36.6 ± 0.2

36.8 ± 0.1

36.5 ± 0.2

36.5 ± 0.3

36.8 ± 0.1

36.7 ± 0.2

pH

7.4 ± 0.03

7.4 ± 0.01

7.4 ± 0.01

7.4 ± 0.01

7.4 ± 0.01

7.4 ± 0.01

7.5 ± 0.01

7.4 ± 0.01

7.5 ±0.01

7.5 ± 0.00

7.5 ± 0.01

7.4 ± 0.01

7.4 ± 0.01

7.4 ± 0.01

7.5 ± 0.01

7.4 ± 0.01

PO2, mm Hg

120 ± 7

106 ± 7

115 ± 9

115 ± 7

113 ± 8

105 ± 5

102 ± 9

109 ± 6

104 ± 6

122 ± 10

96 ± 5

106 ± 7

102 ± 7

103 ± 6

108 ± 14

107 ± 10

PCO2, mm Hg

40.0 ± 2.0

39.0 ± 1.0

38.8 ± 1.0

38.3 ± 0.7

39.4 ± 0.9

40.7 ± 0.5

37.5 ± 0.9

38.9 ± 0.7

37.6 ± 1.0

38.0 ± 0.9

39.0 ± 0.7

38.7 ± 0.8

38.6 ± 0.7

39.6 ± 1.6

47.3 ± 8.4

39.4 ± 1.0

Plasma glucose, mg/dL

151 ± 14

154 ± 8

175 ± 13

181 ± 14

183 ± 18

193 ± 15

173 ± 13

132 ± 1.0

162 ± 14

161 ± 8

160 ± 7

147 ± 7

171 ± 10

156 ± 11

168 ± 11

156 ± 8

Hematocrit, %

44 ± 1.0

43 ± 0.3

44 ± 0.9

44 ± 0.8

44 ± 0.8

44 ± 0.5

42 ± 1.0

45 ± 1.2

45 ± 1.2

43 ± 0.4

45 ± 1.2

43 ± 1.0

46 ± 0.7

44 ± 0.8

45 ± 12

43 ± 1.7

Body weight (g)

334 ± 5

324 ± 8

304 ± 11

320 ± 7

309 ± 6

304 ± 7

334 ± 14

302 ± 4

327 ± 6

317 ± 9

306 ± 8

333 ± 7

335 ± 13

321 ± 11

326 ± 7

330 ± 11

During MCAo (15 min)

                

Rectal temperature (oC)

36.8 ± 0.1

37.2 ± 0.1

37.0 ± 0.1

37.0 ± 0.1

37.3 ± 0.1

37.1 ± 0.1

37.2 ±0.1

36.9±0.1

37.0±0.1

37.2±0.1

37.3±0.1

37.2±0.1

37.1±0.1

37.0±0.2

37.3±0.1

37.1±0.1

Cranial temperature (oC)

36.6 ± 0.1

36.3 ± 0.1

36.6 ± 0.1

36.6 ± 0.1

36.7 ± 0.2

36.6 ± 0.1

37.0 03

37.0±0.0

37.6±0.5

37.0±0.0

37.0±0.2

36.9±0.1

36.9±0.1

36.9±0.1

36.6±0.2

37±0.0

pH

7.4 ± 0.01

7.4 ± 0.01

7.4 ± 0.01

7.4 ± 0.01

7.4 ± 0.02

7.5 ± 0.01

7.4 ± 0.1

7.4±0.01

7.4±0.01

7.5±0.02

7.4±0.02

7.4±0.02

7.4±0.00

7.4±0.01

7.4±0.01

7.4±0.02

PO2, mm Hg

112±8

97 ± 5

99 ± 7

104 ± 5

108 ±7

99 ± 4

98 ± 1

98±4

103±5

105±8

96±5

107±9

113±9

101±6

102±6

97±6

PCO2, mm Hg

40.0 ± 2.0

40.0 ± 0.0

39.2 ± 0.8

40.7 ± 1.0

39.0 ± 0.9

38.4 ± 0.8

41.0 ± 1.4

39.2±0.6

39.1±0.7

39.8±1.0

40.0±1.3

39.5±0.8

39.7±0.6

39.8±0.6

39.3±0.7

40.3±1.7

Plasma glucose, mg/dL

141 ± 7

159 ± 7

176 ± 13

181 ± 14

202 ± 19

189 ± 9

160 ± 10

148±15

150±11

156±9

145±27

151±9

169±11

159±10

149±8

147±8

Hematocrit, %

44 ± 1.0

43 ± 0.4

44 ± 1.0

44 ± 0.7

43 ± 0.4

44 ± 0.5

43 ± 1.4

46±0.5

44.6±1.4

45±0.8

46±0.9

44±1.0

46±0.9

44±1.1

47±1.1

46±1.3

15 min after treatment

                

Rectal temperature(oC)

37.2±0.3

36.6±0.2

37.2±0.1

37.2±0.3

37.1±0.1

37.0±0.1

36.7±0.1

37.0±0.1

37.2±0.2

36.7±0.1

37.0±0.2

37.1±0.1

37.1±0.2

37.1±0.2

37.1±0.2

37.2±0.1

Cranial temperature(oC)

37.2±0.2

36.6±0.2

37.5±0.2

37.9±0.4

37.7±0.3

37.2±0.2

36.1±0.1

36.1±0.1

36.8±0.3

36.3±0.2

36.4±0.3

36.3±0.2

36.8±0.2

36.3±0.3

36.1±0.1

36.8±0.2

Hematocrit, %

45±1.1

44±0.9

37±0.3

40±0.6

37±0.5

35±0.7*

43±1.4

44±1.0

35±1.4*

35±0.8*

38±0.6*

35±0.6*

36±0.8*

36±0.8*

36±0.6*

36±1.1*

1 day after treatment

                

Rectal temperature (oC)

38.3±0.2

38.3±0.2

38.4±0.1

37.8±0.2

38.0±0.3

37.7±0.1

38.0±0.2

38.0±0.2

38.1±0.3

37.8±0.5

37.0±0.2

37.7±0.3

38.0±0.3

37.6±0.2

37.8±0.1

37.7±0.2

Body weight(g)

301±6

300±7

270±10

294±7

287±7

281±6

299±14

275±7

304±9

303±10

283±10

304±10

303±15

294±16

308±9

303±14

7 days after treatment

                

Rectal temperature (oC)

37.8±0.3

38.0±0.2

35.1±1.4

37.6±0.3

37.8±0.2

37.8±0.1

37.7±0.1

37.5±0.2

37.7±0.2

37.7±0.1

36.7±0.9

37.4±0.5

35.8±1.3

37.2±0.2

37.4±0.1

36.4±1.2

Hematocrit, %

44±1.3

40±0.8

47±0.2

41±0.7

45±0.5

43±0.8

45±1.2

41±1.1

40±1.1

42±0.9

39±0.5

39±0.3

41±0.8

39±0.8

40±0.7

39±1.0

Body weight (g)

305±16

319±17

219±12

305±19

307±12

310±7

318±18

297±16

331±14

294±25

311±20

307±21

333±24

304±24

345±7

321±21

  1. Values are mean ± SEM.
  2. MCAo, middle cerebral artery occlusion.
  3. *different from saline group (p<0.05, Student’s t-test).