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Table 1 Physiological variables

From: Docosahexaenoic acid complexed to human albumin in experimental stroke: neuroprotective efficacy with a wide therapeutic window

  Dose-response study Therapeutic window study
  Saline DHA 5 mg/kg Alb 0.63 g/kg DHA-Alb Saline DHA 5 mg/kg Alb, 1.25 g/kg DHA-Alb Alb, 1.25g/kg DHA-Alb
     0.32 g/kg 0.63 g/kg 1.25 g/kg    3h 2h 3h 4h 5h 5h 6h 7h
  (n=6) (n=7) (n=6) (n=7) (n=5) (n=7) (n=7) (n=8) (n=8) (n=8) (n=8) (n=7) (n=9) (n=7) (n=9) (n=8)
Before MCAo (15 min)                 
Rectal temperature (oC) 36.6 ± 0.1 37.3 ± 0.1 37.1 ± 0.1 36.9 ± 0.1 37.3 ± 0.2 37.1 ± 0.1 36.8 ± 0.1 36.9 ± 0.1 37.2 ± 0.1 37.0 ± 0.1 36.9 ± 0.1 36.9 ±0.1 37.0 ± 0.1 36.8 ± 0.1 37.0 ± 0.1 36.8 ± 0.1
Cranial temperature (oC) 36.6 ± 0.1 36.8 ± 0.1 36.9 ± 0.2 36.3 ± 0.1 36.8 ± 0.2 36.6 ± 0.2 36.7 ± 0.3 36.8 ± 0.2 37.1 ± 0.1 36.9 ± 0.1 36.6 ± 0.2 36.8 ± 0.1 36.5 ± 0.2 36.5 ± 0.3 36.8 ± 0.1 36.7 ± 0.2
pH 7.4 ± 0.03 7.4 ± 0.01 7.4 ± 0.01 7.4 ± 0.01 7.4 ± 0.01 7.4 ± 0.01 7.5 ± 0.01 7.4 ± 0.01 7.5 ±0.01 7.5 ± 0.00 7.5 ± 0.01 7.4 ± 0.01 7.4 ± 0.01 7.4 ± 0.01 7.5 ± 0.01 7.4 ± 0.01
PO2, mm Hg 120 ± 7 106 ± 7 115 ± 9 115 ± 7 113 ± 8 105 ± 5 102 ± 9 109 ± 6 104 ± 6 122 ± 10 96 ± 5 106 ± 7 102 ± 7 103 ± 6 108 ± 14 107 ± 10
PCO2, mm Hg 40.0 ± 2.0 39.0 ± 1.0 38.8 ± 1.0 38.3 ± 0.7 39.4 ± 0.9 40.7 ± 0.5 37.5 ± 0.9 38.9 ± 0.7 37.6 ± 1.0 38.0 ± 0.9 39.0 ± 0.7 38.7 ± 0.8 38.6 ± 0.7 39.6 ± 1.6 47.3 ± 8.4 39.4 ± 1.0
Plasma glucose, mg/dL 151 ± 14 154 ± 8 175 ± 13 181 ± 14 183 ± 18 193 ± 15 173 ± 13 132 ± 1.0 162 ± 14 161 ± 8 160 ± 7 147 ± 7 171 ± 10 156 ± 11 168 ± 11 156 ± 8
Hematocrit, % 44 ± 1.0 43 ± 0.3 44 ± 0.9 44 ± 0.8 44 ± 0.8 44 ± 0.5 42 ± 1.0 45 ± 1.2 45 ± 1.2 43 ± 0.4 45 ± 1.2 43 ± 1.0 46 ± 0.7 44 ± 0.8 45 ± 12 43 ± 1.7
Body weight (g) 334 ± 5 324 ± 8 304 ± 11 320 ± 7 309 ± 6 304 ± 7 334 ± 14 302 ± 4 327 ± 6 317 ± 9 306 ± 8 333 ± 7 335 ± 13 321 ± 11 326 ± 7 330 ± 11
During MCAo (15 min)                 
Rectal temperature (oC) 36.8 ± 0.1 37.2 ± 0.1 37.0 ± 0.1 37.0 ± 0.1 37.3 ± 0.1 37.1 ± 0.1 37.2 ±0.1 36.9±0.1 37.0±0.1 37.2±0.1 37.3±0.1 37.2±0.1 37.1±0.1 37.0±0.2 37.3±0.1 37.1±0.1
Cranial temperature (oC) 36.6 ± 0.1 36.3 ± 0.1 36.6 ± 0.1 36.6 ± 0.1 36.7 ± 0.2 36.6 ± 0.1 37.0 03 37.0±0.0 37.6±0.5 37.0±0.0 37.0±0.2 36.9±0.1 36.9±0.1 36.9±0.1 36.6±0.2 37±0.0
pH 7.4 ± 0.01 7.4 ± 0.01 7.4 ± 0.01 7.4 ± 0.01 7.4 ± 0.02 7.5 ± 0.01 7.4 ± 0.1 7.4±0.01 7.4±0.01 7.5±0.02 7.4±0.02 7.4±0.02 7.4±0.00 7.4±0.01 7.4±0.01 7.4±0.02
PO2, mm Hg 112±8 97 ± 5 99 ± 7 104 ± 5 108 ±7 99 ± 4 98 ± 1 98±4 103±5 105±8 96±5 107±9 113±9 101±6 102±6 97±6
PCO2, mm Hg 40.0 ± 2.0 40.0 ± 0.0 39.2 ± 0.8 40.7 ± 1.0 39.0 ± 0.9 38.4 ± 0.8 41.0 ± 1.4 39.2±0.6 39.1±0.7 39.8±1.0 40.0±1.3 39.5±0.8 39.7±0.6 39.8±0.6 39.3±0.7 40.3±1.7
Plasma glucose, mg/dL 141 ± 7 159 ± 7 176 ± 13 181 ± 14 202 ± 19 189 ± 9 160 ± 10 148±15 150±11 156±9 145±27 151±9 169±11 159±10 149±8 147±8
Hematocrit, % 44 ± 1.0 43 ± 0.4 44 ± 1.0 44 ± 0.7 43 ± 0.4 44 ± 0.5 43 ± 1.4 46±0.5 44.6±1.4 45±0.8 46±0.9 44±1.0 46±0.9 44±1.1 47±1.1 46±1.3
15 min after treatment                 
Rectal temperature(oC) 37.2±0.3 36.6±0.2 37.2±0.1 37.2±0.3 37.1±0.1 37.0±0.1 36.7±0.1 37.0±0.1 37.2±0.2 36.7±0.1 37.0±0.2 37.1±0.1 37.1±0.2 37.1±0.2 37.1±0.2 37.2±0.1
Cranial temperature(oC) 37.2±0.2 36.6±0.2 37.5±0.2 37.9±0.4 37.7±0.3 37.2±0.2 36.1±0.1 36.1±0.1 36.8±0.3 36.3±0.2 36.4±0.3 36.3±0.2 36.8±0.2 36.3±0.3 36.1±0.1 36.8±0.2
Hematocrit, % 45±1.1 44±0.9 37±0.3 40±0.6 37±0.5 35±0.7* 43±1.4 44±1.0 35±1.4* 35±0.8* 38±0.6* 35±0.6* 36±0.8* 36±0.8* 36±0.6* 36±1.1*
1 day after treatment                 
Rectal temperature (oC) 38.3±0.2 38.3±0.2 38.4±0.1 37.8±0.2 38.0±0.3 37.7±0.1 38.0±0.2 38.0±0.2 38.1±0.3 37.8±0.5 37.0±0.2 37.7±0.3 38.0±0.3 37.6±0.2 37.8±0.1 37.7±0.2
Body weight(g) 301±6 300±7 270±10 294±7 287±7 281±6 299±14 275±7 304±9 303±10 283±10 304±10 303±15 294±16 308±9 303±14
7 days after treatment                 
Rectal temperature (oC) 37.8±0.3 38.0±0.2 35.1±1.4 37.6±0.3 37.8±0.2 37.8±0.1 37.7±0.1 37.5±0.2 37.7±0.2 37.7±0.1 36.7±0.9 37.4±0.5 35.8±1.3 37.2±0.2 37.4±0.1 36.4±1.2
Hematocrit, % 44±1.3 40±0.8 47±0.2 41±0.7 45±0.5 43±0.8 45±1.2 41±1.1 40±1.1 42±0.9 39±0.5 39±0.3 41±0.8 39±0.8 40±0.7 39±1.0
Body weight (g) 305±16 319±17 219±12 305±19 307±12 310±7 318±18 297±16 331±14 294±25 311±20 307±21 333±24 304±24 345±7 321±21
  1. Values are mean ± SEM.
  2. MCAo, middle cerebral artery occlusion.
  3. *different from saline group (p<0.05, Student’s t-test).