Figure 1

(A) Time course of ICP until 180 minutes after SAH. No significant differences were observed between groups. (B) Time course of dynamic MAP changes until 180 minutes after SAH. MAP was significantly higher before and after SAH when animals were anesthetized with MMF as compared to chloral hydrate or isoflurane. SAH induced a Cushing response (transient increase of MAP due to increased ICP) in animals anesthetized with MMF while no such response was observed in the isoflurane or chloral hydrate groups. ICP and MAP were recorded continuously, averaged over 3 minutes, and displayed as means ± SEM (n = 5 in each group; *p < 0.05 vs. isoflurane, #p < 0.05 vs. chloral hydrate; Kruskal-Wallis ANOVA on ranks followed by Dunn's post-hoc test).