Figure 1
From: Animal models of post-ischemic forced use rehabilitation: methods, considerations, and limitations
Following injury to the forelimb, attempts to use the impaired limb lead to unsuccessful motor attempts. The consequences include pain and failure, creating negative feedback which leads to suppression of the behaviour. Meanwhile, the unaffected or less affected forelimb is used with higher success, leading to reinforced compensation. Together, these constitute the phenomenon of learned non-use. Adapted from Taub et al. [11].