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Table 2 Models of experimental forelimb rehabilitation

From: Animal models of post-ischemic forced use rehabilitation: methods, considerations, and limitations

Rehab model Advantages Disadvantages References
Constraint +Most direct model of CIMT; -Constraint devices may be stressful, confounding results; [25, 27, 75]
+Allows constraint for specific durations thereby allowing the evaluation of various durations of therapy; -Lack of behavioural pressure to use paretic arm despite constraint
+Conducive to studies of unilateral forced use  
Forcing use with locomotion +Stimulates use of the paretic limb in a less aversive paradigm -Can be stressful (involuntary forced use); [27, 57, 7681]
-May lack control over intensity (voluntary forced use);
Encouraging use +Stimulates use of the paretic limb in a less aversive paradigm -Complicated by other non-forced use therapy components such as cognitive stimulation; [8286]
  -Usually involves bilateral forced use
Task specific exercises +An addition to rehabilitation that models task specific shaping exercises of CIMT -Requires the desire of animals to participate in a demanding task [27, 76, 77, 8284, 86]
  1. Summary of advantages and disadvantages of previously described animal models of rehabilitation.