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Figure 2 | Experimental & Translational Stroke Medicine

Figure 2

From: Blood brain barrier breakdown as the starting point of cerebral small vessel disease? - New insights from a rat model

Figure 2

Degenerative small vessel wall changes, small bleeds and infarcts in SHRSP. Degenerative small vessel wall changes include arteriolosclerosis (A &B, hippocampus), lipohyalinosis (C, basal ganglia) and thickening of the extracellular matrix (D, hippocampus &E, basal ganglia) with associated enlarged perivascular spaces (AC). Erythrocytes, leaking through injured small vessel walls, form perivascular bleeds (F &G, cortex). Reactive small vessel occlusions (white asterisks) surrounded by perivascular mini- and microbleeds (H &I, cortex) with consecutive infarcts consisting of spongy, cystic and hemorrhagic tissue (I) are the consequence and represent the final stage of cerebral small vessel disease in SHRSP. A &B – Congo red staining, C, F - I - HE staining, D &E – Movat staining.

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