Arteriolar erythrocyte accumulations in treated and non-treated SHRSP. Arteriolar erythrocyte accumulations in a 18 weeks old (A) and in a 36 weeks (B) non-treated animal and 32 weeks (C) old treated animal. Comparing both groups, the treated and the non-treated SHRSP, those arteriolar erythrocyte accumulations were less detectable in the treated animals (D). Note the initiating (arrow, B) and complete (arrow, C) diapedesis of the intravasal accumulated erythrocytes throughout the damaged small vessel wall leading to microbleeds in the adjacent parenchyma (asterisk, C). A-C HE staining, cortex, magnification 200, ** p ≤ 0.05.