Table 1 Clinical studies assessing the effects of intravenous magnesium in ischemic stroke
From: Magnesium treatment for neuroprotection in ischemic diseases of the brain
Author | Study setup | Treatment arms and comedication | Individuals | Results |
|---|---|---|---|---|
Wester et al., 1984 [40] | Tolerability study | MgSO4 (15 mmol + 96 mmol/24h for 5 days) | 14 patients with ischemic stroke | Magnesium-treatment well tolerated. No information about outcome |
Muir et al., 1995 [41] | Randomized, placebo-controlled | MgSO4 (8 mmol + 65 mmol/kg for 24 hours) vs. placebo | 60 patients with ischemic stroke | Magnesium-treatment well tolerated, tendency to better neurological outcome |
Muir et al., 1998 [16] | Randomized, placebo-controlled | MgSO4 (8, 12 or 16 mmol + 65 mmol/kg for 24 hours) vs. placebo | 25 patients with ischemic stroke | All dose-regimens well tolerated. No difference in outcome |
The IMAGES investigators, 2004 [43] | Randomized, placebo-controlled | MgSO4 (16 mmol + 65 mmol/kg for 24 hours) vs. placebo | 2589 patients with ischemic stroke | No over all reduction of death or disability (primary end-point), trend to benefit in lacunar stroke |