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Table 1 Clinical studies assessing the effects of intravenous magnesium in ischemic stroke

From: Magnesium treatment for neuroprotection in ischemic diseases of the brain

Author Study setup Treatment arms and comedication Individuals Results
Wester et al., 1984 [40] Tolerability study MgSO4 (15 mmol + 96 mmol/24h for 5 days) 14 patients with ischemic stroke Magnesium-treatment well tolerated. No information about outcome
Muir et al., 1995 [41] Randomized, placebo-controlled MgSO4 (8 mmol + 65 mmol/kg for 24 hours) vs. placebo 60 patients with ischemic stroke Magnesium-treatment well tolerated, tendency to better neurological outcome
Muir et al., 1998 [16] Randomized, placebo-controlled MgSO4 (8, 12 or 16 mmol + 65 mmol/kg for 24 hours) vs. placebo 25 patients with ischemic stroke All dose-regimens well tolerated. No difference in outcome
The IMAGES investigators, 2004 [43] Randomized, placebo-controlled MgSO4 (16 mmol + 65 mmol/kg for 24 hours) vs. placebo 2589 patients with ischemic stroke No over all reduction of death or disability (primary end-point), trend to benefit in lacunar stroke
  1. After promising experimental data and a trend to better outcome, a large multicenter clinical trial failed to demonstrate a beneficial effect of intravenous magnesium in the over all study population. Solely the subgroup with lacunar infarction showed a tendency to better recovery after magnesium medication.