Serial brain magnetic resonance imaging (MRI) revealed infarct progression within 2 weeks in spontaneously hypertensive stroke-prone rats (SHRSP). T2-weighted (T2w) sequences (A–D) with coronal slice orientation were performed at the age of 32 weeks (A, B, DfB 0.7 mm, −2.3 mm) and 34 weeks (C, D, DfB 0.5 mm, −2.6 mm) in SHRSP K2R2 and revealed an infarct progression in the basal ganglia with midline shift (D) over time. Both MRI scans and the corresponding histology (E, F) showed a nearly panhemispheric infarct (dashed outline in B–F). Histology revealed a high number of small perivascular hemorrhages (G) and small vessel thromboses in the infarcted area (H). w – age in weeks; DfB – distance from bregma; Scale bar in E and F: 1000 μm. Scale bar in G and H: 50 μm.