Figure 3

Infarct progression and macrohemorrhages in spontaneously hypertensive stroke-prone rats (SHRSP). T2-weighted (T2w) sequences (A–D) with coronal slice orientation were performed at the age of 40 weeks (A, B, DfB −7.3 mm, −5.6 mm) and 42 weeks (C, D, DfB −6.5 mm, −6.1 mm) in SHRSP K1R2 revealed a progression of bilateral cortical infarcts (dashed outline in A–D) and the embedded macrohemorrhage (black arrowheads in B, D) within 2 weeks. Histology showed a high number of small perivascular bleeds (E) and small thromboses in the infarcted area (F). w – age in weeks; DfB – distance from bregma. Scale bar in E–G: 50 μm.