Cerebral perfusion in the ischemic hemisphere of surviving animals at 48 hrs post-stroke as measured with LSCI and calculated as percent of contralateral value. Comparisons between the groups were done “within the experimental set” either without or with IV-tPA. Representative ximages from 3 different animals, and plot from the two experimental sets, A. Experiment I without IV-tPA; +Veh + Sham (N = 7 survived out of 10; 7/10), +MINO + Sham (N = 8/10), +Veh + RIPerC (N = 7/10) and + MINO + RIPerC (N = 10/10), and B. Experiment II with IV-tPA; +Veh + Sham (N = 5 survived out of 10; 5/10), +MINO + Sham (N = 8/10), +Veh + RIPerC (N = 7/10), and + MINO + RIPerC (N = 8/10). For both experiments, data presented as Mean ± SD. Pairs of Means with different letters are significantly different, p < 0.05.