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Table 1 Identified phase III studies

From: Analysis of early phase and subsequent phase III stroke studies of neuroprotectants: outcomes and predictors for success

Study acronym/study title Year of publication Intervention No. of subjects Result
PAIS 2009 Acetaminophen 1400 Neutral
AHAIS 2001 Aptiganel 628 Neutral
BEST 1988 Atenolol, Propanolol 302 Neutral
POST-010 and POST-011 * BMS-204352 1978 Neutral
SCAST 2011 Candesartan 2004 Neutral
Cervene phase 3 2000 Cervene (Nalmefene) 368 Neutral
Citicoline ECCO 2000 2001 Citicoline 899 Neutral
Citicoline 007 1999 Citicoline 394 Neutral
ICTUS 2012 Citicoline 2298 Neutral
CLASS 1999 Clomethiazole 1360 Neutral
CLASS-I 2002 Clomethiazole 1198 Neutral
EGASIS 2006 Diazepam 880 Neutral
MACSI 2013 DP-b99 446 Neutral
EAIS 1998 Ebselen 302 Neutral
EAST 2009 Edaravone 814 Neutral
Eliprodil phase III * Eliprodil 483 Neutral
EAST 2001 Enlimomab 625 negative
ESS 2009 Epoetin Alfa 522 Neutral
Fiblast phase III 2002 Fibroblast growth factor 286 Neutral
FIST 1996 Flunarizine 331 Neutral
Fosphenytoin phase III * Fosphenytoin 462 Neutral
GAIN International 2000 Gavestinel (GV150526) 1804 Neutral
GAIN Americas 2001 Gavestinel (GV150526) 1367 Neutral
EST 1994 GM1 ganglioside 792 Neutral
SASS 1994 GM1 ganglioside 287 Neutral
IASSH 1989 GM1 ganglioside 502 Neutral
ASCLEPIOS 1994 Israpidine 357 Neutral
LUB-INT-13 2000 Lubeluzole 1786 Neutral
Lub 1997 Lubeluzole 721 Neutral
IMAGES 2004 Magnesium 2589 Neutral
PRISTINE 1996 Naftidrofuryl 620 Neutral
ANS 1992 Nimodipine 1064 Neutral
INWEST 1994 Nimodipine 295 negative
TRUST 1990 Nimodipine 1215 Neutral
VENUS 2001 Nimodipine 454 Neutral
SAINT II 2007 NXY-059 3306 Neutral
SAINT I 2006 NXY-059 1722 positive
RREACT 2007 ONO-2506, Arundic acid 841 Neutral
PASS 1997 Piracetam 927 Neutral
mRECT 2009 Repinotan 681 Neutral
ASSIST 2000 Selfotel (CGS19755) 567 Neutral
RANTTAS 1996 Tirilazad mesylate 556 Neutral
RANTTAS II 1998 Tirilazad mesylate 126 Neutral
NEST-2 2009 Transcranial laser therapy 660 Neutral
ASTIN 2003 UK279,276 966 Neutral
ARTIST+ * YM872 312 Neutral
  1. *Study was not published, information on study was obtained from the Internet Stroke Center.