Figure 5

PAM clustering of regulation patterns observed over the training paradigms and regions studied. The gene set of 3616 differently regulated genes was subjected to the PAM algorithm clustering (patterning around medoids) (clusters = 8, average silhouette width = 0.383, distance measure used = correlation). C, control; v, voluntary and f, forced training. While most clusters follow one direction (up or down) from cage controls in the direction control – voluntary – forced training which correlates to the degree of recovery observed in the behavioral tests, a few clusters show divergent behavior for groups of genes in voluntary and forced training (cluster 3, 5, and partially 4).