Table 1 Experimental protocols
From: Platelet rich clots are resistant to lysis by thrombolytic therapy in a rat model of embolic stroke
| Â | Study 1 | Study 2 |
|---|---|---|
Location | Newcastle, Australia | Bad Nauheim, Germany |
Aim | Develop model, Determine spontaneous recanalization rate | Determine recanalization rates with microbubble + sonothrombolysis enhancement of tPA |
Primary Outcome [method] | Recanalization [Laser Doppler] | Recanalization [Laser Doppler] |
Secondary Outcome(s) [method] | Infarct Volumes [TTC], Mortality, Neurological Deficit scores | Clot lysis [Inspection of the major branches of the cerebral arterial circulation] |
Survival post-embolism | 24Â h | 2Â h |
Treatment groups (n) | No treatment (n = 7) | Saline (n = 10), tPA (n = 10), tPA + Ultrasound + BR38 microbubbles (n = 10) |
Laser Doppler Monitoring | Continuous | Discontinuous |
To 4Â h post-embolism | Pre-embolism, Post-embolism, Pre-treatment, Post-treatment |