Fig. 1

Reperfusion is essential for candesartan induced functional outcome improvement. Sub-hypotensive dose of candesartan conferred neuroprotective effect after stroke in a reperfusion dependent manner (A). In addition, the ability of candesartan to improve functional outcome is also reperfusion dependent (B). *p < 0.05, a, b pairs of means with different letters are significantly different from each other. n = 8–14 per group