Fig. 3

Reperfusion is necessary for candesartan induced activation of survival signaling and ER stress amelioration. Candesartan induced neuroprotection involves the activation of Akt (A) and GSK3-β signaling (B). Lack of reperfusion blunts the ability of candesartan to activate intracellular survival signals. Groups connected by line are significantly different from each other. a,b pairs of means with different letters are significantly different from each other. n = 4 per group