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Fig. 4 | Experimental & Translational Stroke Medicine

Fig. 4

From: Artery reopening is required for the neurorestorative effects of angiotensin modulation after experimental stroke

Fig. 4

Candesartan increases the expression of Nogo-A, and reduced VEGF and MMPs activity in non-reperfused brains. Candesartan administration in animals exposed to permanent middle cerebral artery occlusion increased Nogo-A expression in both hemispheres (A). Candesartan administration significantly reduced VEGF expression (B) and MMP2 and 9 activities (C and D, respectively). Groups connected by line are significantly different from each other. A, B pairs of means with different letters are significantly different from each other. n = 4 per group

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