From: Indoleamine-2,3-dioxygenase activity in experimental human endotoxemia
Time course after LPS infusion | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Variables | Pre-Dose | 1 h | 1.5 h | 2 h | 2.5 h | 3.5 h | 4.5 h | 6.5 h | 8 h | 24 h | P-value |
HEMODYNAMICS | |||||||||||
SBP (mmHg) | 140 ± 14 | 139 ± 11 | 152 ± 11 | 158 ± 18* | 151 ± 18 | 142 ± 22 | 121 ± 18* | 107 ± 11* | 104 ± 11* | 131 ± 11 | <0.0001 |
DBP (mmHg) | 74 ± 10 | 74 ± 7 | 80 ± 7 | 77 ± 12 | 65 ± 12 | 61 ± 14* | 54 ± 11* | 55 ± 8* | 55 ± 7* | 66 ± 7 | <0.0001 |
MAP (mmHg) | 96 ± 11 | 96 ± 9 | 104 ±7 | 104 ± 13 | 94 ± 14 | 88 ± 16 | 77 ± 13* | 72 ± 8* | 71 ± 7* | 88 ± 7 | <0.0001 |
Heart rate (bpm) | 61 ± 16 | 59 ± 11 | 78 ± 19 | 78 ± 18 | 92 ± 12 | 98 ± 8 | 101 ± 8 | 97 ± 11 | 96 ± 13 | 81 ± 16 | <0.0001 |
HR/MAP index | 0.64 ± 0.11 | 0.62 ± 0.11 | 0.75 ± 0.17 | 0.76 ± 0.22 | 1.01 ± 0.22* | 1.15 ± 0.26* | 1.36 ± 0.32* | 1.36 ± 0.27* | 1.4 ± 0.22* | 0.92 ± 0.16* | <0.0001 |
TRYPTOPHAN METABOLISM | |||||||||||
IDOc activity | 29.4 ± 6.8 | 30.5 ± 7.4 | 30.3 ± 6.2 | 30.2 ± 6.8 | 30.2 ± 6.4 | 28.2 ± 3.6 | 28.6 ± 7.2 | 38.1 ± 10.9* | 44.0 ± 15.2* | 36.3 ± 12.3* | <0.0001 |
ADHESION MOLECULES | |||||||||||
sEsel (ng/ml) | 34 ± 16 | 38 ± 18 | 35 ± 16 | 40 ± 18 | 44 ± 24 | 82 ± 48 | 184 ± 90* | 289 ± 133* | 243 ± 95* | 208 ± 81* | <0.0001 |
sVCAM-1 (ng/ml) | 307 ± 108 | 330 ± 120 | 315 ± 103 | 326 ± 100 | 319 ± 109 | 326 ± 122 | 403 ± 86* | 542 ± 92* | 550 ± 91* | 553 ± 130* | <0.0001 |