From: Impact of anesthesia on pathophysiology and mortality following subarachnoid hemorrhage in rats
physiological conditions | after SAH | |||||||
---|---|---|---|---|---|---|---|---|
Preparation | 0 min | 60 min | 180 min | 0 min | 60 min | 180 min | ||
Ventilation rate (v/min) | chloral hydrate | 36 ± 1 | 36 ± 2 | 46 ± 3* | 47 ± 3* | 37 ± 1 | 39 ± 2 | 42 ± 4* |
isoflurane | 35 ± 2 | 44 ± 4* | 51 ± 2* | 58 ± 2* | 44 ± 2 | 43 ± 2 | 47 ± 3* | |
MMF | 32 ± 2 | 30 ± 2 | 29 ± 2 | 27 ± 1 | 35 ± 3 | 35 ± 4 | 34 ± 3 | |
Art. pCO2 (mmHg) | chloral hydrate | 36.9 ± 2.9 | 41.6 ± 2.8 | 41.8 ± 2.5 | 40.8 ± 3.4 | 40.5 ± 1.7 | 41.7 ± 2.2 | 43.2 ± 3.0 |
isoflurane | 44.2 ± 1.9 | 45.1 ± 3.1 | 41.7 ± 4.0 | 42.9 ± 2.7 | 38.6 ± 0.8 | 44.1 ± 2.0 | 42.4 ± 2.9 | |
MMF | 40.3 ± 3.1 | 37.1 ± 1.2 | 34.5 ± 2.4 | 37.8 ± 3.3 | 41.7 ± 0.6 | 44.3 ± 2.3 | 43.3 ± 3.1 | |
Art. pO2 (mmHg) | chloral hydrate | 136.6 ± 4.1 | 120.3 ± 3.4 | 116.0 ± 6.3# | 113.1 ± 4.7# | 125.1 ± 6.8# | 116.5 ± 7.1# | 109.6 ± 9.4 |
isoflurane | 121.1 ± 4.2 | 105.1 ± 7.8 | 89.6 ± 2.8 | 86.4 ± 3.9 | 99.8 ± 5.3 | 92.3 ± 3.1 | 90.1 ± 5.6 | |
MMF | 125.6 ± 9.5 | 122.2 ± 9.7 | 135.6 ± 8.8# | 135.4 ± 6.7# | 105.2 ± 8.0 | 106.2 ± 6.9# | 116.1 ± 9.5 | |
pH | chloral hydrate | 7.29 ± 0.03 | 7.30 ± 0.02 | 7.29 ± 0.02 | 7.28 ± 0.03 | 7,34 ± 0,02 | 7.33 ± 0.01 | 7,28 ± 0,02 |
isoflurane | 7.29 ± 0.02 | 7.32 ± 0.05 | 7.33 ± 0.04 | 7.35 ± 0.03 | 7,33 ± 0,01 | 7.29 ± 0.01 | 7,31 ± 0,03 | |
MMF | 7.34 ± 0.07 | 7.37 ± 0.01 | 7.35 ± 0.02 | 7.35 ± 0.01 | 7,37 ± 0,02 | 7.34 ± 0.04 | 7,35 ± 0,01 | |
Glucose (mg/dl) | chloral hydrate | 196 ± 24 | 231 ± 20 | 169 ± 14 | 115 ± 16 | 186 ± 27 | 162 ± 23 | 138 ± 18 |
isoflurane | 165 ± 20 | 158 ± 20 | 120 ± 10 | 114 ± 6 | 131 ± 15 | 121 ± 9 | 128 ± 8 | |
MMF | 196 ± 51 | 191 ± 37 | 156 ± 23 | 174 ± 26 | 208 ± 43 | 173 ± 17 | 181 ± 24 | |
Lactate ( mmol/l) | chloral hydrate | 1.0 ± 0.1 | 1.1 ± 0.1 | 0.8 ± 0.1 | 0.6 ± 0.1 | 1.2 ± 0.3 | 1.4 ± 0.3 | 0.7 ± 0.1 |
isoflurane | 1.0 ± 0.1 | 1.3 ± 0.1 | 1.4 ± 0.2 | 1.5 ± 0.3 | 1.2 ± 0.3 | 0.8 ± 0.1 | 1.0 ± 0.0 | |
MMF | 0.5 ± 0.1 | 0.6 ± 0.0 | 0.7 ± 0.1 | 0.8 ± 0.2 | 0.6 ± 0.0 | 1.1 ± 0.1 | 0.8 ± 0.2 |