Table 2 Expression and regulation of ABC transporters in the immortalised human brain microvascular endothelial cell line hCMEC/D3 after hypoxia and after ischemia/reperfusion
Gene | RQ of hypoxic compared to normoxic samples (Range) | RQ of I/R compared to normoxic samples (Range) | ||
|---|---|---|---|---|
ABCA1 | 0.79 | (0.45-1.38) | 0.83 | (0.54-1.28) |
ABCA2 | 0.70 | (0.42-1.16) | 0.70 | (0.54-0.91) |
ABCA3 | 0.85 | (0.57-1.25) | 0.76 | (0.59-0.98) |
ABCA4 | 0.55 | (0.32-0.94) | 0.69 | (0.36-1.34) |
ABCA5 | 0.70 | (0.47-1.05) | 0.63 | (0.51-0.78) |
ABCA6 | 0.89 | (0.62-1.29) | 1.01 | (0.63-1.63) |
ABCA7 | 0.90 | (0.56-1.45) | 0.76 | (0.60-0.96) |
ABCA8 | 0.69 | (0.42-1.13) | 0.62 | (0.42-0.92) |
ABCA9 | 0.97 | (0.43-2.23) | 0.86 | (0.52-1.41) |
ABCA10 | 0.69 | (0.43-1.11) | 0.48 | (0.33-0.69) |
ABCB1 | 0.57 | (0.39-0.85) | 0.60 | (0.47-0.75) |
ABCB2 | 0.81 | (0.55-1.20) | 0.89 | (0.70-1.15) |
ABCB3 | 0.54 | (0.35-0.85) | 0.67 | (0.47-0.95) |
ABCB6 | 0.80 | (0.50-1.28) | 0.58 | (0.47-0.71) |
ABCB7 | 0.75 | (0.51-1.11) | 0.64 | (0.51-0.81) |
ABCB8 | 0.76 | (0.47-1.22) | 0.71 | (0.50-1.02) |
ABCB9 | 0.74 | (0.48-1.13) | 0.51 | (0.35-0.75) |
ABCB10 | 0.92 | (0.60-1.42) | 0.60 | (0.46-0.77) |
ABCC1 | 0.48 | (0.33-0.71) | 0.49 | (0.39-0.61) |
ABCC2 | 0.82 | (0.48-1.39) | 1.03 | (0.71-1.51) |
ABCC3 | 0.59 | (0.40-0.85) | 0.57 | (0.44-0.74) |
ABCC4 | 0.54 | (0.37-0.79) | 0.52 | (0.40-0.68) |
ABCC5 | 0.72 | (0.45-1.15) | 0.75 | (0.40-1.42) |
ABCC10 | 0.79 | (0.48-1.29) | 0.63 | (0.48-0.82) |
ABCD1 | 0.52 | (0.30-0.90) | 0.51 | (0.25-1.02) |
ABCD3 | 0.52 | (0.34-0.79) | 0.40 | (0.27-0.61) |
ABCD4 | 0.84 | (0.55-1.28) | 0.98 | (0.63-1.51) |
ABCE1 | 0.60 | (0.41-0.87) | 0.51 | (0.38-0.69) |
ABCF1 | 0.80 | (0.53-1.18) | 0.70 | (0.54-0.91) |
ABCF2 | 0.55 | (0.34-0.88) | 0.53 | (0.43-0.64) |
ABCF3 | 0.76 | (0.49-1.20) | 0.74 | (0.46-1.17) |
ABCG1 | 0.99 | (0.68-1.44) | 0.97 | (0.76-1.23) |
ABCG2 | 0.87 | (0.59-1.27) | 0.53 | (0.36-0.78) |