Figure 4

Detection of intravasal erythrocyte thrombi. In vivo imaging was performed before brain slices were investigated by HE-staining. Comparison of the results independently revealed from both techniques showed quite well matched data in only one animal (SHRSP 712, Table  1). Here, the intravitally suspected arteriolar (B, white arrow) and capillary (B, white arrowhead) erythrocyte thrombi match those found histologically (A, inlay shows an exemplary arteriolar erythrocyte thrombus). In contrast, data of SHRSP 711 (Table  1) represent exemplary results indicative of the mismatch between imaging and histological data found in the remaining animals. Here, arteriolar erythrocyte thrombi were suspected with 2 PM (D, white arrow), but no arteriolar erythrocyte thrombi were found within the whole surgical area (C). w – age in weeks, scale bars = 50 μm.