Figure 8
Histopathology: Effect of DHA treatment on infarct areas and volumes. (A) Representative computer generated mosaic images of Nissl-stained brain sections from the rats treated with DHA or saline at 72 h after MCAo. DHA showed a smaller cortical and subcortical infarct compared to saline treated animal. (B) Infarct areas at standardized bregma levels. DHA decreased cortical and total infarct areas at multiple bregma levels compared to vehicle group. (C) Infarct volume in cortex, subcortex and total hemisphere. DHA-treated animals were observed significant reduction of cortical and total infarct volume compared to vehicle-treated animals. Values are mean ± SEM; n = 5-6 rats per group. *Significantly different form corresponding saline group (p < 0.05, repeated measures ANOVA followed by Bonferroni tests: comparison of infarct areas; Student’s T-test: comparison of infarct volume).