Figure 3
From: The PGE2 EP2 receptor and its selective activation are beneficial against ischemic stroke
EP2 receptor deletion increases neurologic deficit scores and infarct volume in mice subjected to tMCAO. Mice were subjected to 90-min tMCAO and evaluated for neurologic deficits at 4 days. After being scored, the mice were sacrificed, and brain infarction was estimated by TTC staining. (A) Representative photographs show infarcted brain slices from WT (left) and EP2-/- (right) mice. (B) The bar graph shows the corrected cortical, striatal, and hemispheric infarct volumes of WT and EP2-/- mice. The infarct size was significantly larger in EP2-/- (n = 14) than in WT mice (n = 9). (C) Neurologic deficit scores at 4 days after ischemia were significantly higher in EP2-/- mice than in WT mice, indicating more neurologic dysfunction. **P < 0.01.