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Experimental & Translational Stroke Medicine

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  1. Content type: Review

    The renin angiotensin system (RAS) consists of the systemic hormone system, critically involved in regulation and homeostasis of normal physiological functions [i.e. blood pressure (BP), blood volume regulatio...

    Authors: Mariana Moreira Coutinho Arroja, Emma Reid and Christopher McCabe

    Citation: Experimental & Translational Stroke Medicine 2016 8:8

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  2. Content type: Review

    Cerebral hyperperfusion is a relatively rare syndrome with significant and potentially preventable clinical consequences. The pathophysiology of cerebral hyperperfusion syndrome (CHS) may involve dysregulation...

    Authors: Muhammad U. Farooq, Christopher Goshgarian, Jiangyong Min and Philip B. Gorelick

    Citation: Experimental & Translational Stroke Medicine 2016 8:7

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  3. Content type: Research

    Suspected transient ischaemic attack (TIA) is a common presentation to emergency medical services (EMS) in the United Kingdom (UK). Several EMS systems have adopted the ABCD2 score to aid pre-hospital risk str...

    Authors: Scott Munro, Sally Rodbard, Khalid Ali, Claire Horsfield, Wendy Knibb, Janet Holah, Ottilia Speirs and Tom Quinn

    Citation: Experimental & Translational Stroke Medicine 2016 8:6

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  4. Content type: Research

    Blood flow restoration with fibrinolysis and thrombectomy is recommended to limit injury in stroke patients with proximal artery occlusion. Angiotensin receptor blockers have been shown to be neuroprotective i...

    Authors: Ahmed Alhusban, Anna Kozak, Wael Eldahshan, Adviye Ergul and Susan C. Fagan

    Citation: Experimental & Translational Stroke Medicine 2016 8:4

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    The Erratum to this article has been published in Experimental & Translational Stroke Medicine 2016 8:5

  5. Content type: Meeting report

    From October 30–November 1, 2015, the 7th NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. Seventy doctoral students and postdocs from over 25 different groups working in German and Swiss Unive...

    Authors: Thomas Korn, Christoph Kleinschnitz, Tim Magnus, Sven G. Meuth and Ralf A. Linker

    Citation: Experimental & Translational Stroke Medicine 2016 8:3

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  6. Content type: Review

    Cerebral collateral circulation is a subsidiary vascular network, which is dynamically recruited after arterial occlusion, and represents a powerful determinant of ischemic stroke outcome. Although several met...

    Authors: Elisa Cuccione, Giada Padovano, Alessandro Versace, Carlo Ferrarese and Simone Beretta

    Citation: Experimental & Translational Stroke Medicine 2016 8:2

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  7. Content type: Research

    No evidence-based therapy is available for patients with acute intracerebral hemorrhage (ICH). In view of the profound inflammatory reaction in the perilesional tissue, we investigated in a well-characterized ...

    Authors: Frieder Schlunk, Waltraud Pfeilschifter, Kazim Yigitkanli, Eng H. Lo and Christian Foerch

    Citation: Experimental & Translational Stroke Medicine 2016 8:1

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  8. Content type: Research

    Ischemic brain injury disrupts the blood–brain barrier (BBB) and then triggers a cascade of events, leading to edema formation, secondary brain injury and poor neurological outcomes. Recently, we have shown th...

    Authors: Sung-Ha Hong, Larissa Khoutorova, Nicolas G Bazan and Ludmila Belayev

    Citation: Experimental & Translational Stroke Medicine 2015 7:3

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  9. Content type: Research

    Early recanalization of occluded vessels in stroke is closely associated with improved clinical outcome. Microbubble-enhanced sonothrombolysis is a promising therapy to improve recanalization rates and reduce ...

    Authors: Amelia J Tomkins, Nadine Schleicher, Lucy Murtha, Manfred Kaps, Christopher R Levi, Max Nedelmann and Neil J Spratt

    Citation: Experimental & Translational Stroke Medicine 2015 7:2

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  10. Content type: Meeting report

    From October 31th – November 2nd, 2014, the 6th NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. 70 doctoral students and postdocs from over 25 different groups working in German and Swiss univ...

    Authors: Christoph Kleinschnitz, Ralf A Linker, Tim Magnus, Thomas Korn and Sven G Meuth

    Citation: Experimental & Translational Stroke Medicine 2015 7:1

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  11. Content type: Short report

    Sterile inflammation is a substantial element of post-stroke pathophysiology with the determination of autoimmunity versus tolerance being one of its most important aspects. It is believed that this determinat...

    Authors: Claudia Pösel, Anna Uri, Isabell Schulz, Johannes Boltze, Gesa Weise and Daniel-Christoph Wagner

    Citation: Experimental & Translational Stroke Medicine 2014 6:11

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  12. Content type: Research

    After the failure of so many drugs and therapies for acute ischemic stroke, innovative approaches are needed to develop new treatments. One promising strategy is to test combinations of agents in the pre-hospi...

    Authors: Md Nasrul Hoda, Susan C Fagan, Mohammad B Khan, Kumar Vaibhav, Aizaz Chaudhary, Phillip Wang, Krishnan M Dhandapani, Jennifer L Waller and David C Hess

    Citation: Experimental & Translational Stroke Medicine 2014 6:10

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  13. Content type: Research

    The role of autophagy in response to ischemic stroke has been confusing with reports that both enhancement and inhibition of autophagy decrease infarct size and improve post-stroke outcomes. We sought to clari...

    Authors: Kathleen M Buckley, Daniel L Hess, Irina Y Sazonova, Sudharsan Periyasamy-Thandavan, John R Barrett, Russell Kirks, Harrison Grace, Galina Kondrikova, Maribeth H Johnson, David C Hess, Patricia V Schoenlein, Md Nasrul Hoda and William D Hill

    Citation: Experimental & Translational Stroke Medicine 2014 6:8

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  14. Content type: Short report

    The brain endothelium is a key component of the blood brain barrier which is compromised following ischemia, allowing infiltration of damaging immune cells and other inflammatory molecules into the brain. Intr...

    Authors: Alexander Widiapradja, Tomislav Santro, Milan Basta, Christopher G Sobey, Silvia Manzanero and Thiruma V Arumugam

    Citation: Experimental & Translational Stroke Medicine 2014 6:7

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  15. Content type: Research

    Although there are many experimental studies describing the methodology of the middle cerebral artery occlusion (MCAO) in the literature, only limited data on these distinct anatomical structures and the detai...

    Authors: Aslan Güzel, Roland Rölz, Guido Nikkhah, Ulf D Kahlert and Jaroslaw Maciaczyk

    Citation: Experimental & Translational Stroke Medicine 2014 6:6

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  16. Content type: Research

    Efforts to develop stroke treatments have met with limited success despite an intense need to produce novel treatments. The failed translation of many of these therapies in clinical trials has lead to a close ...

    Authors: Simon R Platt, Shannon P Holmes, Elizabeth W Howerth, Kylee Jo J Duberstein, C Robert Dove, Holly A Kinder, Emily L Wyatt, Amie V Linville, Vivian W Lau, Steven L Stice, William D Hill, David C Hess and Franklin D West

    Citation: Experimental & Translational Stroke Medicine 2014 6:5

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  17. Content type: Short report

    The role of the immune system in the pathophysiology of acute ischemic stroke is increasingly recognized. However, targeted treatment strategies to modulate immunological pathways in stroke are still lacking. ...

    Authors: Peter Kraft, Kerstin Göbel, Sven G Meuth and Christoph Kleinschnitz

    Citation: Experimental & Translational Stroke Medicine 2014 6:4

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  18. Content type: Research

    Both the immobilization of the unaffected arm combined with physical therapy (forced arm use, FAU) and voluntary exercise (VE) as model for enriched environment are promising approaches to enhance recovery aft...

    Authors: Armin Schneider, Andreas Rogalewski, Oliver Wafzig, Friederike Kirsch, Norbert Gretz, Carola Krüger, Kai Diederich, Claudia Pitzer, Rico Laage, Christian Plaas, Gerhard Vogt, Jens Minnerup and Wolf-Rüdiger Schäbitz

    Citation: Experimental & Translational Stroke Medicine 2014 6:3

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  19. Content type: Research

    Efficacy of neuroprotective treatments for ischemic stroke was not convincingly demonstrated in clinical phase III trials so far, whereas some preceding early phase studies found neuroprotection to be benefici...

    Authors: Jens Minnerup, Heike Wersching, Matthias Schilling and Wolf Rüdiger Schäbitz

    Citation: Experimental & Translational Stroke Medicine 2014 6:2

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  20. Content type: Research

    There is growing evidence that endothelial failure and subsequent blood brain barrier (BBB) breakdown initiate cerebral small vessel disease (CSVD) pathology. In spontaneously hypertensive stroke-prone rats (S...

    Authors: Solveig Niklass, Stoyan Stoyanov, Cornelia Garz, Celine Z Bueche, Stine Mencl, Klaus Reymann, Hans-Jochen Heinze, Roxana O Carare, Christoph Kleinschnitz and Stefanie Schreiber

    Citation: Experimental & Translational Stroke Medicine 2014 6:1

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  21. Content type: Research

    Brain ischemia is known to include neuronal cell death and persisting neurological deficits. A lack of oxygen and glucose are considered to be key mediators of ischemic neurodegeneration while the exact mechan...

    Authors: Petra Ehling, Eva Göb, Stefan Bittner, Thomas Budde, Andreas Ludwig, Christoph Kleinschnitz and Sven G Meuth

    Citation: Experimental & Translational Stroke Medicine 2013 5:16

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  22. Content type: Meeting report

    From october 25th - 27th 2013, the 5th NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. This year more than 60 doctoral students and postdocs from over 25 different groups working in German uni...

    Authors: Ralf A Linker, Tim Magnus, Thomas Korn, Christoph Kleinschnitz and Sven G Meuth

    Citation: Experimental & Translational Stroke Medicine 2013 5:15

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