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Figure 1 | Experimental & Translational Stroke Medicine

Figure 1

From: Safety evaluation of a recombinant plasmin derivative lacking kringles 2-5 and rt-PA in a rat model of transient ischemic stroke

Figure 1

Rat snare ligature model. The head of the rat was immobilized in a specially designed head holder. A skin incision was made between the eye and external auditory canal. The MCA was exposed by bisecting the temporalis muscle and performing a craniotomy anteriomedial to the juncture of the zygomatic arch with the squamosal bone. The dura was opened using a tuberculin syringe and the MCA was isolated from the arachnoid and pia by blunt dissection. Left Panel: construction of the snare ligature. Middle Panel: occlusion of the middle cerebral artery. Right Panel: removal of the snare ligature resulting in recanalization.

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