Infarct volumes 24 hours after permanent middle cerebral artery occlusion. Infarct volumes 24 hours after pMCAo measured with 2D nucleator and Cavalieri’s principle. Infarct volume in cortex was significantly larger in WT mice (n = 6, 7.6 mm³ SE ± 0.35 mm³) compared to matching Ngb-null (n = 9 5.7 mm³ SE ± 0.41 mm³) littermates. p < 0. 0076. Lines indicate mean values and * denote significance.