Figure 1

Dose response study: (A) Total neurological score (normal score=0, maximal score=12) during MCAo and at various times after treatment. Saline, DHA 5 mg/kg), Albumin (0.63 g/kg) or DHA-Albumin (5 mg/kg + 0.32, 0.63 or 1.25 g/kg) treatment was administered at 3 h after onset of ischemia. (B) Histopathology on day 7 of survival. All doses of DHA-Alb significantly reduced cortical, subcortical and total (cortical and subcortical) corrected infarct volume compared to Alb-treated rats. Data are mean ±SEM; n=5-7 per group. *P <0.05 versus saline group; ^# P <0.05 versus Alb group (repeated-measures ANOVA followed by Bonferroni tests).