Figure 1

a-d Functional and structural changes of retinal vessels in colorectal cancer patients in response to bevacizumab infusion. While the diameter of retinal vessels were unaffected by bevacizumab treatment (Figure 1 a) it evoked an increase in arteriolar-to-venular ratio (Figure 1 b) and a decrease in flicker-induced arterial vasodilation (Figure 1 c). The reactivity of retinal arteries to flickering light tended to be lower in patients with a pathological nocturnal blood pressure profile (non-dippers) than in those with physiological nocturnal blood pressure profile (dippers) (Figure 1 d). Legend: before (day-1) and after (day + 1) bevacizumab infusion.