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Figure 1 | Experimental & Translational Stroke Medicine

Figure 1

From: Early microvascular dysfunction in cerebral small vessel disease is not detectable on 3.0 Tesla magnetic resonance imaging: a longitudinal study in spontaneously hypertensive stroke-prone rats

Figure 1

Cortical and hippocampal small vessel thromboses, small perivascular bleeds, infarcts, and macrohemorrhages in spontaneously hypertensive stroke-prone rats (SHRSP). T2-weighted (T2w) sequences (A, distance from bregma −5 mm) and hematoxylin–eosin staining (B) with coronal slice orientation performed at the age of 30 weeks in SHRSP K1R1 showed bilateral cortical and hippocampal infarcts (dashed outline in A, B) as well as macrohemorrhages (black arrowheads in A, B). The corresponding histology displayed small vessel thromboses (black arrowheads in C) and a high number of small perivascular bleeds within the infarcted areas (exemplary ones marked with black arrowheads in D). w – age in weeks; Scale bar in B: 1000 μm; Scale bar in C and D: 50 μm.

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