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Table 1 Study design for the experiment I (without IV-tPA; 1a), and experiment II (with IV-tPA; 1b)

From: A 2 × 2 factorial design for the combination therapy of minocycline and remote ischemic perconditioning: efficacy in a preclinical trial in murine thromboembolic stroke model

a, Experiment I: Without IV-tPA post-stroke
  No MINO (IV-Saline 1 hr post-stroke) Yes MINO (IV-MINO 1 hrs post-stroke)
No RIPerC (RIPerC Sham at 2 hrs post-stroke) Saline, RIPerC Sham (+Veh+Sham Group) MINO, RIPerC Sham (+MINO Group)
Yes RIPerC (RIPerC Therapy at 2 hrs post-stroke) Saline, RIPerC Therapy (+Veh+RIPerC Group) MINO, RIPerC Therapy (+MINO+RIPerC Group)
b, Experiment II: With IV-tPA (or vehicle) at 4 hrs post-stroke
  No MINO (IV-Saline 1 hr post-stroke) Yes MINO (IV-MINO 1 hrs post-stroke)
No RIPerC (RIPerC Sham at 2 hrs post-stroke) Saline, RIPerC Sham (+Veh+Sham Group) MINO, RIPerC Sham (+MINO Group)
Yes RIPerC (RIPerC Therapy at 2 hrs post-stroke) Saline, RIPerC Therapy (+Veh+RIPerC Group) MINO, RIPerC Therapy (+MINO+RIPerC Group)